Microsystems to study the mechanobiology of cell adhesion
Abstract/Contents
- Abstract
- Adherent cell functions can be altered by mechanical stimuli through cytoskeleton remodeling and cell-cell junction disruption. Thus, a better understanding of the mechanical response of adherent cells is crucial to the design of pharmacological therapies for cancers and skin blistering diseases. However, a lack of reliable tools to apply mechanical stimuli and probe the cellular response has limited research on the effects of varying strains on adherent cells. Therefore, I develop systems to probe cellular mechanics using microfabrication technology with soft materials specifically designed to exert controlled strain on adherent cells and probe their mechanical response.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2015 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Sim, Joo Yong |
|---|---|
| Associated with | Stanford University, Department of Mechanical Engineering. |
| Primary advisor | Pruitt, Beth |
| Thesis advisor | Pruitt, Beth |
| Thesis advisor | Dunn, Alexander Robert |
| Thesis advisor | Nelson, William |
| Advisor | Dunn, Alexander Robert |
| Advisor | Nelson, William |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Joo Yong Sim. |
|---|---|
| Note | Submitted to the Department of Mechanical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Joo Yong Sim
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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