Mechanistic metabolic interactions between gut microbiota and host
Abstract/Contents
- Abstract
- The trillions of bacteria inhabiting the mammalian gastrointestinal tract, known as the gut microbiota, comprise a diverse community and exert wide-ranging systemic effects on the host. Members of the microbiota harbor diverse metabolic capability, are able to consume substrates unavailable to the host, and produce molecules that are not encoded by the human genome. This biochemical cross-talk between microbes and host constitutes an important avenue for signaling between the microbiota and host and coevolution of the mutualistic relationship. As such, metabolism is a valuable lens through which to explore the host-microbe relationship. This work presents four mechanisms by which metabolic interactions shape the ways in which members of the gut microbiota and the host interact: 1) A new understanding for the ways in which the enteric pathogen Clostridium difficile leverages inflammation to alter its metabolic activity in the gut as well as 2) persist during homeostatic conditions. 3) A prebiotic that shapes the microbiota in ways beneficial to the host, and 4) a previously unidentified mechanism for host detoxification of microbially-produced metabolites
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Pruss, Kali Meredith |
|---|---|
| Degree supervisor | Sonnenburg, Justin, 1973- |
| Thesis advisor | Sonnenburg, Justin, 1973- |
| Thesis advisor | Huang, Kerwyn Casey, 1979- |
| Thesis advisor | Monack, Denise M |
| Thesis advisor | Spormann, Alfred M |
| Degree committee member | Huang, Kerwyn Casey, 1979- |
| Degree committee member | Monack, Denise M |
| Degree committee member | Spormann, Alfred M |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Kali Meredith Pruss |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Kali Meredith Pruss
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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