Supplementary data on macrophage cells for thesis entitled: "Advances on chip inside a cell for monitoring physiological cell parameters"
Continuous monitoring of physiological parameters inside a living cell will lead to major advances in understanding of biology and complex diseases, such as cancer. It also enables us to develop new medical diagnostics and therapeutics. In addition, progress in nanofabrication and wireless communication has opened up the potential of making our wireless chip small enough that it can be wholly inserted into a cell. To investigate how the chip could be internalized into the cell and how the chip would affect cell physiology, we designed and fabricated a series of 3D multilayer structures with different sizes as a potential RFID (Radio Frequency IDentification) cell tracker. Our experiments show that the chips with smaller sizes than 21 micron x 9 micron x 1.5 micron can be easily internalized by various types of living cells, such as macrophages, cancer cells, and normal/healthy cells. The incubated cells with internalized chips stayed alive during the 5 days of monitoring. Also, we observed successful cell division from these incubated cells. These results are the first steps towards long-term, wireless, intracellular physiologic monitoring.
This data set contains short and long videos of cell division or internalization (as indicated in the file names) of macrophages cells incubating microscale silicon chips of 4 different sizes -- 12 micron x 12 micron, 9 micron x 15 micron, 9 micron x 18 micron, and 9 micron x 21 micron.
|Type of resource
|moving image, software, multimedia
|Parizi, Kokab B.
|McConnell, Michael V.
|Silicon Tag Internalization
|Cell Division After Internalization
|Parizi, Kokab B. (2016). Advances on chip inside a cell for monitoring physiological cell parameters (Doctoral dissertation). Stanford Digital Repository. Available at https://purl.stanford.edu/rt889wc7961
|Stanford University. Libraries
- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
- Preferred Citation
- Parizi, Kokab B. and Saito, Toshinobu and Xu, Xiaoqing and Chen, Lisa and Kosuge, Hisanori and McConnell, Michael V. and Wong, H.S-Philip. (2017). Supplementary data on macrophage cells for thesis entitled: "Advances on chip inside a cell for monitoring physiological cell parameters." Stanford Digital Repository. Available at: http://purl.stanford.edu/tg827dt7345
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