Biomimetic design for advanced heart failure technologies
Abstract/Contents
- Abstract
- Cardiovascular disease is the leading cause of death worldwide, with heart failure (HF) affecting over 23 million people. Heart transplantation is the only definitive treatment for advanced HF, but the unavailability of transplantable hearts imposes severe limitations. Prosthetic devices have the potential to address this critical shortage of organs. Biomimicry provides an opportunity to use healthy cardiac physiology as a template for device design. This work employs a needs-first design approach and leverages biomimicry, computational systems, and mechanical design tools to improve the biocompatibility and durability of mechanical cardiac support. The clinical need addressed by this work is right heart failure, the "forgotten half of the heart." For decades, the left ventricle has received disproportionately more attention, and the development of devices for right ventricular (RV) dysfunction has languished. The pivotal role of RV dysfunction in surgical outcomes is now recognized as a substantial clinical burden, particularly in perioperative settings of left-sided procedures. Using metamaterial design, this work presents RVEX, a biomimetic, elastic sleeve to support RV-specific motion by tuning regional mechanical properties of an auxetic lattice. The device can be implanted prophylactically during left-sided procedures to prevent volume overload, a primary failure mode. RVEX is shown to reproduce RV-specific regional deformations and provide support by passive elastic recoil. Integrated self-sensing capabilities also demonstrate the utility of continuous volume monitoring to track ventricular functional status. Additionally, this work presents eVaC, a soft, implantable electrohydraulic actuator for acute ventricular unloading of the RV by vascular pulsation. eVaC is integrated with a sensing module through a simple control scheme for adaptive physiological response. In-vitro experiments demonstrate eVaC's ability to accurately modulate pulsatile pressures to a clinically relevant extent. Computational modeling further predicts the improvement of hemodynamic and biomechanical function of the ventricle. Together, these devices represent a trend toward smart, mechanoactive prosthetic devices that are more biocompatible and expected to yield improved patient outcomes.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Pirozzi, Ileana |
|---|---|
| Degree supervisor | Cutkosky, Mark R |
| Thesis advisor | Cutkosky, Mark R |
| Thesis advisor | Hiesinger, William |
| Thesis advisor | Marsden, Alison (Alison Leslie), 1976- |
| Thesis advisor | Yock, Paul G |
| Degree committee member | Hiesinger, William |
| Degree committee member | Marsden, Alison (Alison Leslie), 1976- |
| Degree committee member | Yock, Paul G |
| Associated with | Stanford University, Department of Bioengineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Ileana Pirozzi. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/tf376fj9299 |
Access conditions
- Copyright
- © 2022 by Ileana Pirozzi
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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