Neural dynamics of motor preparation and tools for large scale neuroscience
Abstract/Contents
- Abstract
- A central goal of systems neuroscience is to relate an organism's neural activity to behavior. Current state of the art experimental methods are limited both in the capability of recording from large populations of neurons simultaneously, as well as in the complexity of the behaviors studied. In this work, I describe the development of new tools and methods for recording from large populations of neurons in rhesus macaque nonhuman primates (NHP). In addition, I describe the development of a haptic robotic interface to implement more complex motor tasks. I use this apparatus to study how short timescale adaptation to dynamic loads alters neural preparatory activity in premotor and primary motor cortices prior to movements. Chapter 1 provides an introduction and in-depth overview of the work covered in the remaining four chapters of this dissertation. Chapter 2 describes efforts to estimate neural population dynamics using multiunit threshold crossings in place of well isolated single units, which potentially eliminates a time consuming, difficult, and inexact portion of data analysis that serves as bottleneck for discovery. In Chapter 3, I describe the development of two-photon calcium imaging for rhesus macaque monkeys performing motor behaviors and the implementation of an optical brain machine interface (oBMI). In Chapter 4, I describe the development of techniques for using high-density silicon electrodes, such as the Neuropixels probe, in NHP. Lastly, in Chapter 5, I describe the development of a haptic experiment in which we introduce a simulated drag force and investigate the impact of short timescale adaptation to these dynamic loads on motor preparation.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Trautmann, Eric |
|---|---|
| Degree supervisor | Shenoy, Krishna V. (Krishna Vaughn) |
| Thesis advisor | Shenoy, Krishna V. (Krishna Vaughn) |
| Thesis advisor | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Thesis advisor | Ganguli, Surya, 1977- |
| Thesis advisor | Newsome, William T |
| Degree committee member | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Degree committee member | Ganguli, Surya, 1977- |
| Degree committee member | Newsome, William T |
| Associated with | Stanford University, Neurosciences Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Eric Trautmann. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Eric Morton Trautmann
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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