Molecular mechanisms regulating neural circuit assembly in caenorhabditis elegans
Abstract/Contents
- Abstract
- Nervous system function, from sensory perception to motor control, requires precisely neural circuit assembly. Therefore, elucidating the molecular and cellular mechanisms which establish and maintain functional neural circuit is of fundamental importance to our understanding of the brain. We develop a novel repressible binary expression system in C. elegans being able to manipulate neural circuit more precisely. We demonstrate that the unfolded protein response (UPR) regulates dendrite morphogenesis of a polymodal nociceptive neuron PVD. Finally, we propose the sex-dimorphic Dosage Compensation Complex (DCC) may regulate synaptic specificity in the pheromone sensory circuit. These results suggest that a diverse assemblage of molecular and cellular mechanisms are necessary for the precise and appropriate assembly of neural circuits. These mechanisms can be elucidated using simple nematode C. elegans in a reductionist manner.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Wei, Xing |
|---|---|
| Associated with | Stanford University, Department of Biology. |
| Primary advisor | Shen, Kang, 1972- |
| Thesis advisor | Shen, Kang, 1972- |
| Thesis advisor | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Thesis advisor | Kopito, Ron Rieger |
| Thesis advisor | Luo, Liqun, 1966- |
| Advisor | Clandinin, Thomas R. (Thomas Robert), 1970- |
| Advisor | Kopito, Ron Rieger |
| Advisor | Luo, Liqun, 1966- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Xing Wei. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Xing Wei
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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