Molecular mechanisms of STING signaling
Abstract/Contents
- Abstract
- The innate immune STING pathway exists at a unique tipping point in cell signaling: not enough STING activation leaves cells vulnerable to cancer or viral infection, while too much STING signaling causes inflammation and autoimmunity. It is therefore paramount that we understand the complete molecular mechanism of how STING is activated and regulated. Here I describe the use of structural and biochemical techniques to elucidate a more complete molecular picture of STING activation. l explain how these findings have led us toward a molecular tool for inhibiting STING activation, which may prove valuable for the future treatment of autoimmune and inflammatory syndromes. Finally, I discuss how STING is activated and regulated in the context of the cell, which gives us clues into how it delivers an effective and robust immune response without causing harmful inflammatory effects.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Ergun, Sabrina Lindsey |
|---|---|
| Degree supervisor | Li, Lingyin |
| Thesis advisor | Li, Lingyin |
| Thesis advisor | Harbury, Pehr |
| Thesis advisor | Rohatgi, Rajat |
| Thesis advisor | Yeh, Ellen |
| Degree committee member | Harbury, Pehr |
| Degree committee member | Rohatgi, Rajat |
| Degree committee member | Yeh, Ellen |
| Associated with | Stanford University, Department of Biochemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Sabrina Ergun. |
|---|---|
| Note | Submitted to the Department of Biochemistry. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/sz396vy1186 |
Access conditions
- Copyright
- © 2021 by Sabrina Lindsey Ergun
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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