Multi-dimensional imaging of immune response
Abstract/Contents
- Abstract
- Improvements in our understanding of the immune system have led to radical paradigm shifts in medicine including the advent of vaccines and cancer immunotherapy. New "high-dimensional" techniques promise to guide the next generation of immune based therapies, yet thus far, have failed to fully predict patient response or elucidate therapeutic mechanism of action. For this, a "multi-dimensional" approach is needed, as immunity occurs across space, time, and scale (e.g. cells to organ systems). To realize this goal, an immuno-imaging toolbox capable of multi-dimensional interrogation of immune response was built. This dissertation describes engineering principles learned and biological insights gained from developing imaging probes capable of non-invasively monitoring whole body immune response across space and time. This dissertation discusses how to select and validate appropriate imaging biomarkers of immune response, and provides several examples of applications for immuno-imaging in monitoring cancer immunotherapies. Some of the approaches and imaging probes developed in this work are currently being clinically translated for applications from selecting the right cancer patients for immune checkpoint inhibitors, to diagnosing and preventing immune-mediated organ transplant rejection. The state-of-art immuno-imaging toolbox described herein provides a previously unprecedented "multi-dimensional" view of the immune system in action and has the potential to guide future patient care.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Mayer, Aaron Thomas |
|---|---|
| Degree supervisor | Gambhir, Sanjiv Sam |
| Thesis advisor | Gambhir, Sanjiv Sam |
| Thesis advisor | Levin, Craig |
| Thesis advisor | Lin, Michael Z |
| Degree committee member | Levin, Craig |
| Degree committee member | Lin, Michael Z |
| Associated with | Stanford University, Department of Bioengineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Aaron Thomas Mayer. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Aaron Thomas Mayer
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...