Pathogenic bacterial innate immune evasion mechanisms
Abstract/Contents
- Abstract
- Typhoid fever is caused by the human-restricted bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi), and each year this bacterium is estimated to cause 11-21 million new infections worldwide. With increasing rates of antibiotic resistance and the emergence of extensively drug resistant S. Typhi strains, the development of novel therapeutics to treat typhoid fever and clear the infection is critical. To achieve this requires a deep understanding of S. Typhi's interaction with and response to the host. It is also important to know how the host's immune system responds to S. Typhi infections. A deep, mechanistic understanding of host-pathogen interactions could reveal novel ways to inhibit S. Typhi or modulate the host's immune response to combat the pathogen. My thesis examines how S. Typhi responds to cues from the host to evade innate immune detection and host innate immune responses to bacterial infection.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Brewer, Susan Matlock |
|---|---|
| Degree supervisor | Monack, Denise M |
| Thesis advisor | Monack, Denise M |
| Thesis advisor | Amieva, Manuel |
| Thesis advisor | Mudgett, Mary Beth, 1967- |
| Thesis advisor | Schneider, David (David Samuel) |
| Degree committee member | Amieva, Manuel |
| Degree committee member | Mudgett, Mary Beth, 1967- |
| Degree committee member | Schneider, David (David Samuel) |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Susan Matlock Brewer. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2020. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Susan Matlock Brewer
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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