Complex adaptation in subdivided populations
Abstract/Contents
- Abstract
- Adaptations that give rise to new biological functions are often complex, emerging through the interaction of multiple mutations. A complex adaptation may require a set of mutations that are beneficial only in combination. To adapt, a lineage must acquire mutations that are individually neutral or deleterious before gaining the beneficial combination, thereby crossing a plateau or valley, respectively, in the mapping from genotype to fitness. This thesis explores how spatial population structure affects the rate at which populations adapt across fitness valleys and plateaus through the analysis of theoretical models of populations that are subdivided into discrete subpopulations linked by migration.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | McLaren, Michael Robert |
|---|---|
| Associated with | Stanford University, Department of Biology. |
| Primary advisor | Feldman, Marcus W |
| Thesis advisor | Feldman, Marcus W |
| Thesis advisor | Fisher, Daniel |
| Thesis advisor | Petrov, Dmitri Alex, 1969- |
| Thesis advisor | Rosenberg, Noah |
| Advisor | Fisher, Daniel |
| Advisor | Petrov, Dmitri Alex, 1969- |
| Advisor | Rosenberg, Noah |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Michael Robert McLaren. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Michael Robert McLaren
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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