Dissecting multiple origins of heterogeneity in RNA folding
Abstract/Contents
- Abstract
- Structured RNAs are central to many biological processes. For structured RNAs to carry out their function, they must fold into a correct structure and often undergo conformational changes while carrying out their function. When RNA folding, conformational change and function have been studied at the single molecule level, it has been commonly observed that individual molecules can have distinct properties that persist over long timescales. However, the origins of this molecular heterogeneity were unknown. The research presented in this dissertation uncover that heterogeneity in RNA folding can arise from multiple sources. This understanding helped elucidate features of RNA folding landscapes that were not previously appreciated. Furthermore, it demonstrated that understanding the origins of heterogeneity for a particular RNA is key to developing models that accurately describe the overall folding.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2012 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Greenfeld, Max |
|---|---|
| Associated with | Stanford University, Department of Chemical Engineering |
| Primary advisor | Herschlag, Daniel |
| Primary advisor | Khosla, Chaitan, 1964- |
| Thesis advisor | Herschlag, Daniel |
| Thesis advisor | Khosla, Chaitan, 1964- |
| Thesis advisor | Spakowitz, Andrew James |
| Advisor | Spakowitz, Andrew James |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Max Greenfeld. |
|---|---|
| Note | Submitted to the Department of Chemical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2012. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Max Greenfeld
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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