Defining the human innate immune response to dengue virus infection
Abstract/Contents
- Abstract
- Dengue virus (DENV), a serious cause of morbidity in the Americas and Southeast Asia, is the most prevalent arthropod-borne virus in the world. During DENV infection, innate immune cells not only serve as a first line of defense, but also as sites of viral replication. Consequently, their response to infection affects the extent of viral spread and activation of the adaptive immune response. Here we present three stories exploring the innate immune response to DENV infection with a focus on natural killer (NK) cells and monocytes. We first examine how upregulation of HLA class I molecules by DENV-infected cells serves to suppress the NK cell response. Next, we investigate how the immune response to DENV infection differs between children and adults, with a particular focus on changes in the NK cell receptor-ligand repertoire. Finally, we explore the susceptibility of different monocyte subsets to the two different routes of dengue infection: direct infection and antibody-dependent enhancement (ADE). To conclude, we discuss some new questions that have arisen from this work and propose future studies
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | McKechnie, Julia Luna |
|---|---|
| Degree supervisor | Blish, Catherine |
| Thesis advisor | Blish, Catherine |
| Thesis advisor | Carette, Jan, 1971- |
| Thesis advisor | Kim, Peter, 1958- |
| Thesis advisor | Martinez, Olivia |
| Thesis advisor | Wang, Taia |
| Degree committee member | Carette, Jan, 1971- |
| Degree committee member | Kim, Peter, 1958- |
| Degree committee member | Martinez, Olivia |
| Degree committee member | Wang, Taia |
| Associated with | Stanford University, Department of Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Julia Luna McKechnie |
|---|---|
| Note | Submitted to the Department of Immunology |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Julia Luna McKechnie
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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