Two sides of the same coin : separable inhibitory action against GLI and ALDH1B1 activity
Abstract/Contents
- Abstract
- Small molecules are powerful tools that enable the interrogation of complex biological questions and provide insights into routes for modulating these processes. Furthermore, small molecules often provide a framework for the design of novel therapeutics with relevant disease targets. In this dissertation, I present my work employing a family of bicyclic imidazolium compounds towards the inhibition of the Hedgehog (Hh) signaling pathway and the aldehyde dehydrogenase ALDH1B1. These studies have enhanced our understanding of specific molecular mechanisms that drive cancer, and potential routes to mitigate tumorigenicity driven by GLI or ALDH1B1.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Hom, Marisa |
|---|---|
| Degree supervisor | Chen, James Kenneth |
| Thesis advisor | Chen, James Kenneth |
| Thesis advisor | Dixon, Scott James, 1977- |
| Thesis advisor | Meyer, Tobias, 1979- |
| Thesis advisor | Mochly-Rosen, Daria |
| Degree committee member | Dixon, Scott James, 1977- |
| Degree committee member | Meyer, Tobias, 1979- |
| Degree committee member | Mochly-Rosen, Daria |
| Associated with | Stanford University, Department of Chemical and Systems Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Marisa E. Hom. |
|---|---|
| Note | Submitted to the Department of Chemical and Systems Biology. |
| Thesis | Thesis Ph.D. Stanford University 2020. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Marisa Hom
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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