The development of new methods for the intracellular delivery and release of messenger RNA and other biological polyanions using amphipathic molecular transporters
Abstract/Contents
- Abstract
- The noncovalent, electrostatic complexation of an anionic cargo with a cationic molecular transporter represents a powerful strategy for the protection and delivery of otherwise cell-impermeable molecules. The work described herein has been directed at developing new, biodegradable transporters using the organocatalytic ring-opening polymerization of functionalized cyclic monomers. These transporters effectively self-assemble with polyanionic cargo such as nucleic acids like mRNA and siRNA, and inositol polyphosphates and deliver them to cells and living animals. We anticipate that the delivery and release strategies developed using responsive oligomeric biomaterials will contribute to further work aimed at both basic research and therapeutic applications of complex biological polyanions.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Vargas, Jessica Renae |
|---|---|
| Associated with | Stanford University, Department of Chemistry. |
| Primary advisor | Wender, Paul A |
| Thesis advisor | Wender, Paul A |
| Thesis advisor | Du Bois, Justin |
| Thesis advisor | Waymouth, Robert M |
| Advisor | Du Bois, Justin |
| Advisor | Waymouth, Robert M |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Jessica Renae Vargas. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Jessica Renae Vargas
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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