A deeper dive with photons
Abstract/Contents
- Abstract
- Subtitle-- Recent breakthroughs in optical-based imaging in nonhuman primates promise to fundamentally advance our understanding of brain function and accelerate the development of next-generation brain-computer interfaces.Summary-- Two new studies demonstrate complementary approaches for imaging the activity patterns of large populations of neurons in nonhuman primates (NHPs).-- Bollimunta*, Santacruz* & colleagues used a head-mounted one-photon miniature microscope to image the activity of neurons deep in the motor cortex of a behaving macaque, and demonstrated the ability to perform offline decoding of the animal’s motor behavior using the same neurons tracked over weeks.-- Trautmann*, O’Shea*, Sun* & colleagues used two-photon microscopy to image the activity of neurons, also in the motor cortex, and show that it is possible to access deep cortical neurons by imaging their apical dendrites near the surface, allowing them to perform online, closed-loop decoding of the behaving macaque’s motor behavior sufficient to drive an optical brain-computer interface (BCI).-- Together, these studies pave the way for new experiments to understand how populations of neurons underlie behavior, and how new BCI technologies can treat neurological injury and disease.
Description
| Type of resource | text |
|---|---|
| Date created | 2021 |
| Publication date | 2021 |
Creators/Contributors
| Author | Nassi, Jonathan J. |
https://orcid.org/https://orcid.org/0000-0002-3144-3846
(unverified)
|
|---|---|---|
| Author | Trautmann, Eric |
https://orcid.org/https://orcid.org/0000-0001-5552-2023
(unverified)
|
Subjects
| Subject | optical imaging |
|---|---|
| Subject | 1 photon |
| Subject | fiber |
| Subject | endoscopy |
| Subject | 2 photon |
| Subject | GCaMP |
| Subject | CLARITY |
| Subject | microscopy |
| Subject | BCI |
| Genre | Technical report |
| Genre | Technical report |
Bibliographic information
| Related publication | Bollimunta, A., Santacruz, S.R., Eaton, R.W., Xu, P.S., Morrison, J.H., Moxon, J.H., Carmena, J.M., and Nassi, J.J. (2021). Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque. Cell Reports 35 109239. https://doi.org/10.1016/j.celrep.2021.109239 |
|---|---|
| Related publication | Trautmann, E.M., O’Shea, D.J., Sun, X., Marshel, J., Crow, A., Hsueh, B., Vesuna, S.A., Cofer, L., Bohner, G., Allen, W., Kauvar, I., MacDougall, M., Ramakrishnan, C., Sahani, M., Seidemann, E., Ryu, S., Deisseroth, K., and Shenoy, K. (2021). Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface. Nature Communications. 12:1-20. https://doi.org/10.1038/s41467-021-23884-5 |
| DOI | https://doi.org/10.25740/sg031pr3479 |
| Location | https://purl.stanford.edu/sg031pr3479 |
Access conditions
- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
Preferred citation
- Preferred citation
- Nassi JJ, Trautmann EM (2021) A deeper dive with photons. Technical Report #02, Version 1.1. Stanford Digital Repository (SDR), Stanford University. https://purl.stanford.edu/sg031pr3479. https://doi.org/10.25740/sg031pr3479
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