Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice
Abstract/Contents
- Abstract
- Neurons in the lateral hypothalamus expressing the neuropeptide Hypocretin, also known as orexin, are known critical modulators of arousal stability. However, their role in the different components of the arousal construct such as attention and decision making is poorly understood. Here we studied Hypocretin neuronal circuit dynamics during stop action impulsivity in a Go NoGo task in mice. We show that Hypocretin neuronal activity correlates with anticipation of reward. We assessed the causal role of Hypocretin neuronal activity using optogenetics in a Go/No Go task. We show that stimulation of Hypocretin neurons during the cue period dramatically increased the number of premature responses. These effects were mimicked by amphetamine, reduced by atomoxetine, a norepinephrine uptake inhibitor, and blocked by a Hypocretin receptor 1 selective antagonist. We conclude that Hypocretin neurons have a key role in the integration of salient stimuli during wakefulness to produce appropriate and timely responses to rewarding and aversive cues.
Description
| Type of resource | Dataset |
|---|---|
| Date created | [ca. February 2022] |
| Publication date | December 13, 2022; December 10, 2022 |
Creators/Contributors
| Author | Tyree, Susan |
|---|---|
| Author | Jennings, Kimberly |
| Author | Gonzalez, Oscar |
| Author | Li, Shi-bin |
| Author | Nicholson, Janet |
| Author | von Heimendahl, Moritz |
| Research team head | de Lecea, Luis |
Subjects
| Subject | orexin, orexin receptor 1 antagonist, pharmacology, Go/NoGo task, optogenetic stimulation, fiber photometry |
|---|---|
| Genre | Data |
| Genre | Documentation |
| Genre | Data sets |
| Genre | Dataset |
Bibliographic information
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- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
- License
- This work is licensed under a Creative Commons Attribution 4.0 International license (CC BY).
Preferred citation
- Preferred citation
- Tyree, S., Jennings, K., Gonzalez, O., Li, S., and Nicholson, J. (2022). Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice . Stanford Digital Repository. Available at https://purl.stanford.edu/sf095mv6553. https://doi.org/10.25740/sf095mv6553.
Collection
Stanford Research Data
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- Contact
- llecea@stanford.edu
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