A scalable, practical approach to neural modulation & recording
Abstract/Contents
- Abstract
- Electrical recording and stimulation is one of the most promising modalities for next generation Brain Machine Interface (BMI) technologies, benefiting from being unhindered by the requirement of genetic modification (a significant barrier to practical deployment), while still being capable of single cell precision. Furthermore, large numbers of electrodes are becoming a critical requirement for next-generation neural interfaces. Electrode to brain interfaces have numerous applications, including neuro-prosthetics, treatment of disorders including epilepsy, depression, Alzheimer's, and restoring function for speech, eyesight, and motion. Microwire based BMI technology is extremely appealing, given the low-immunogenicity and little physiological damage shown during and after implantation of individual microwires. However, scaling from a few wires that are each individually connectorized to more than a thousand wires in parallel has not been possible. Here we describe a new methodology whereby we perform heterogeneous integration of a bundle of microwires (e.g., a large number of microwires collected together into a cylindrically packed aggregate) to a CMOS microchip with yields > 95%, and precise microwire spacing, critical for mitigating tissue damage. This architecture allows for each wire to be independently addressable for recording and/or stimulation purposes, ameliorating issues of scalability. We additionally demonstrate massively parallel recording using a mouse model, showing both spiking activity from single neurons and local field potentials. Lastly, we explore the mechanics of microwire insertion by directly measuring force & displacement in traditional brain mimics, freshly removed murine brains (ex vivo), and in vivo. Using flat polished (FP), angle polished (AP), and electro-sharpened (ES) microwires, we quantify the dimpling of the pia and associated vasculature to < 10 nm displacements, whilst measuring the force of pia puncture and beyond as it relates to wire diameter and tip geometry. Moreover, insertions were measured while observing with 2-photon microscopy, allowing us to directly view local vasculature and astrocytic populations, directly relating force of insertion to damage dealt.
Description
| Alternative title | A scalable, practical approach to neural modulation and recording |
|---|---|
| Type of resource | text |
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Hanna, Mina-Elraheb |
|---|---|
| Associated with | Stanford University, Department of Materials Science and Engineering. |
| Primary advisor | Melosh, Nicholas A |
| Thesis advisor | Melosh, Nicholas A |
| Thesis advisor | Salleo, Alberto |
| Thesis advisor | Schaefer, Andreas, (Professor) |
| Advisor | Salleo, Alberto |
| Advisor | Schaefer, Andreas, (Professor) |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Mina-Elraheb Hanna. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Mina-Elraheb Saad Hanna
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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