Radio-frequency penetrable positron emission tomography (PET) insert for simultaneous PET and magnetic resonance imaging
Abstract/Contents
- Abstract
- Combining medical imaging modalities that measure complementary, multi-parametric information such as anatomy and biochemistry about a patient's disease has been proven to provide tremendous clinical value. In recent years, hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) has risen to the cutting edge of multi-modality medical imaging technology. Unfortunately, the cost of purchasing a commercially-available integrated PET/MRI scanner is unaffordable for most healthcare providers, therefore limiting the dissemination of PET/MRI and its long-term potential. This dissertation presents the development of a radio-frequency (RF)-penetrable PET insert that can be placed into any existing MRI system to acquire simultaneous PET and MRI images. The insert approach can reduce the cost barrier for an existing MRI site to offer PET/MRI scans by leveraging its existing infrastructure. A brain-sized prototype PET insert with a 2.8-cm axial field-of-view (FoV) has been developed and its performance (energy, timing, spatial, system stability, and count rate) evaluated. Tomographic images of resolution and 3-D Hoffman brain phantoms have been acquired with the PET insert both outside and inside and simultaneous running with a 3T MR system. A second-generation RF-penetrable PET insert with an extended axial field-of-view (16 cm) and a coincidence timing resolution (< 300 picosecond full-width-at-half-maximum) capable of time-of- flight (TOF) measurement is currently under development. Two out of a total of sixteen detector modules have been developed and their performance evaluated. A novel PET detector design based on a phoswich configuration capable of both excellent coincidence timing resolution and photon depth-of-interaction measurements has also been developed and tested to improve spatial resolution uniformity of the insert.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Chang, Chen Ming |
|---|---|
| Degree supervisor | Levin, Craig |
| Degree supervisor | Miller, D. A. B |
| Thesis advisor | Levin, Craig |
| Thesis advisor | Miller, D. A. B |
| Thesis advisor | Glover, Gary H |
| Degree committee member | Glover, Gary H |
| Associated with | Stanford University, Department of Applied Physics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Chen Ming Chang. |
|---|---|
| Note | Submitted to the Department of Applied Physics. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Chen Ming Chang
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