Antibody approaches to enable hematopoietic stem cell and organ transplant
Abstract/Contents
- Abstract
- Clinical care has been greatly advanced by precision medicine, which has been represented by antibodies, chimeric antigen receptor T-cells, small molecule inhibitors to mutant proteins, and many other therapies. The mainstay of this progress has been the purification of the target of interest. As we move into a new era in medicine, therapies should aim to fix the clinical problem at hand while leaving the rest of a patient's body unperturbed. In the case of a tissue or organ system, the identification of the stem cell can allow for either targeted removal or repopulation of that tissue. The former is best exemplified by the identification of cancer stem cells (CSCs), which represent a rare, self-renewing population of malignant cells that have the capacity to differentiate and recapitulate the entire makeup of a bulk tumor. Targeted therapies to CSCs have long been desired as non-specific therapies that work by attacking rapidly dividing cells may cull a large mass but if they leave quiescent CSCs untouched, there may be a chance of recurrence. The following body of work will dive further into this topic and describe a study that yielded a putative CSC population in pancreatic neuroendocrine tumors, as well as potential targeted therapies. The latter scenario of tissue repopulation is best exemplified by bone marrow transplantation, where one's entire hematopoietic system can be replaced by donor blood forming stem cells. This technique is utilized for curing hematopoietic malignancies and genetic disorders; however, its use is limited by side effects related to the non-specific drugs used to prepare a patient for transplant and the impure donor cell grafts that are infused. This dissertation will also discuss work that outlines a novel approach for specifically ablating and engrafting hematopoietic stem cells (HSCs) that was made possible by the purification and subsequent characterization of this population by others
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | George, Benson M |
|---|---|
| Degree supervisor | Weissman, Irving L |
| Thesis advisor | Weissman, Irving L |
| Thesis advisor | Mackall, Crystal |
| Thesis advisor | Majeti, Ravindra, 1972- |
| Thesis advisor | Roncarolo, Maria-Grazia |
| Thesis advisor | Shizuru, Judith Anne |
| Degree committee member | Mackall, Crystal |
| Degree committee member | Majeti, Ravindra, 1972- |
| Degree committee member | Roncarolo, Maria-Grazia |
| Degree committee member | Shizuru, Judith Anne |
| Associated with | Stanford University, Cancer Biology Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Benson M. George |
|---|---|
| Note | Submitted to the Cancer Biology Program |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Benson M George
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
Also listed in
Loading usage metrics...