Lost in translation : investigating new roles for methyl lysine signaling in the regulation of protein synthesis and cancer pathogenesis
Abstract/Contents
- Abstract
- Protein lysine methylation is a common type of post-translational modification that plays a crucial role in various cellular processes. The enzymes responsible for catalyzing these methylation reactions are known as lysine methyltransferases (KMTs). While KMTs have been extensively studied in the context of chromatin regulation and histone methylation, it is increasingly recognized that non-histone protein methylation also plays a significant role in fundamental biological and pathological processes. However, numerous human KMTs remain uncharacterized, and the biological significance of many lysine methylation events is still unknown. In this work, I characterize SMYD5 (SET and MYND domain containing 5), an orphan human KMT. I demonstrate that SMYD5 methylation regulates protein synthesis, particularly active ribosomal function, and specifically enhances mRNA translation for oncogenic programming, facilitating the evolution of malignant gastric cancer. I also propose that inhibiting SMYD5 could serve as a potential cornerstone for combination therapy to treat GAC. The following chapter presents rigorously validated resources that enhance our understanding of the physiological functions of eEF1A methylation, a key modulator of the protein synthesis machinery. These tools will facilitate subsequent research aimed at exploring fundamental biological process. In summary, this study broadens our understanding of methyl-lysine signaling by examining an unidentified enzyme's physiological roles in cancer pathology. Moreover, this work provides robust methodological resources that expedite advancements in the study of protein methylation-based cellular signaling, particularly in the context of human health and disease.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Park, Juhyung |
|---|---|
| Degree supervisor | Gozani, Or |
| Thesis advisor | Gozani, Or |
| Thesis advisor | Dixon, Scott |
| Thesis advisor | Morrison, Ashby |
| Thesis advisor | van Rechem, Capucine |
| Degree committee member | Dixon, Scott |
| Degree committee member | Morrison, Ashby |
| Degree committee member | van Rechem, Capucine |
| Associated with | Stanford University, School of Humanities and Sciences |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Juhyung Park. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/rs160wm5688 |
Access conditions
- Copyright
- © 2023 by Juhyung Park
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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