Biorisk Management Case Study: United States Department of Energy Joint Genome Institute

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Abstract/Contents

Abstract

The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a user facility that offers a variety of capabilities to the scientific community, including DNA sequencing, single cell genomics, metabolomics, and DNA synthesis/engineering biology approaches. Since 2013, synthetic biology proposals submitted to the JGI have been assessed for the broader aspects and implications of the research, beyond technical feasibility and scientific merit. It uses a qualitative approach to evaluate the broader aspects of proposals:
• Proposers submit written qualitative responses to a short set of open-ended questions as part of their application.
• The JGI takes steps to ensure the active engagement of project proposers.
• Following a review of scientific potential, proposals are evaluated by small diverse teams of three external reviewers.
• Reviewers are asked to consider a range of potential issues, including biosafety, biosecurity, ethical, legal, social, and environmental concerns.
• So far, proposals have never been rejected on broader aspects grounds, but proposers are sometimes asked to provide more information or even modify their project.

Description

Date modified February 28, 2023
Publication date February 28, 2023; February 2023

Creators/Contributors

Author Hillson, Nathan
Author Harmon-Smith, Miranda
Author Simirenko, Lisa
Author Greene, Daniel ORCiD icon https://orcid.org/0000-0003-2576-8588 (unverified)
Author Brink, Kathryn ORCiD icon https://orcid.org/0000-0002-5155-9336 (unverified)
Research team head Palmer, Megan ORCiD icon https://orcid.org/0000-0001-8310-2325 (unverified)
Research team head Evans, Samuel ORCiD icon https://orcid.org/0000-0001-8547-3314 (unverified)

Subjects

Subject Risk management
Genre Other
Genre Case study

Bibliographic information

Related item
Preferred citation
Alexanian, T., Millett, P., Greene, D. and Brink, K. (2023). Biorisk Management Case Study: International Genetically Engineered Machine Foundation. Stanford Digital Repository. Available at https://purl.stanford.edu/cc191wv3999. https://doi.org/10.25740/cc191wv3999.
Preferred citation
Bleijs, R. and Brink, K. (2023). Biorisk Management Case Study: National Institute for Public Health and the Environment Biosecurity Office. Stanford Digital Repository. Available at https://purl.stanford.edu/bq389xk1015. https://doi.org/10.25740/bq389xk1015.
Preferred citation
Gordon, B., Casini A., Salm, M., and Brink, K. (2023). Biorisk Management Case Study: Massachusetts Institute of Technology-Broad Foundry. Stanford Digital Repository. Available at https://purl.stanford.edu/mq491gw2822. https://doi.org/10.25740/mq491gw2822.
Preferred citation
Gylling, L., Olsen, K. N., and Brink, K. (2023). Biorisk Management Case Study: Centre for Biosecurity and Biopreparedness. Stanford Digital Repository. Available at https://purl.stanford.edu/bz140yy7585. https://doi.org/10.25740/bz140yy7585.
Preferred citation
Greene, D., Brink, K., Salm, M., Hoffmann, C., Evans, S., and Palmer, M. (2023). The Biorisk Management Casebook: Insights into contemporary practices. Stanford Digital Repository. Available at https://purl.stanford.edu/hj505vf5601. https://doi.org/10.25740/hj505vf5601.
Preferred citation
Hurtley, S., Hoffmann, C., Salm, M., Greene, D., andBrink, K. (2023). Biorisk Management Case Study: Science.Stanford Digital Repository. Available at https://purl.stanford.edu/qr280xp6531. https://doi.org/10.25740/qr280xp6531.
Preferred citation
Junior, M., Hoffmann, C., and Greene, D. (2023). Biorisk Management Case Study: American Society for Microbiology Journals. Stanford Digital Repository. Available at https://purl.stanford.edu/wb258gg9708. https://doi.org/10.25740/wb258gg9708.
Preferred citation
Moritz, R., Blair, H., Marlenee, N., Ryan, J., Greene, D., and Brink, K. (2023). Biorisk Management Case Study: Colorado State University Biosafety Office. Stanford Digital Repository. Available at https://purl.stanford.edu/ck629kc3503. https://doi.org/10.25740/ck629kc3503.
DOI https://doi.org/10.25740/rr427mq4842
Location https://purl.stanford.edu/rr427mq4842

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Preferred citation

Hillson, N., Harmon-Smith, M., Simirenko, L., Greene, D., and Brink, K. (2023). Biorisk Management Case Study: United States Department of Energy Joint Genome Institute. Stanford Digital Repository. Available at https://purl.stanford.edu/rr427mq4842. https://doi.org/10.25740/rr427mq4842.

Collection

Visibility Initiative for Responsible Science (VIRS): Biorisk Management Casebook and Case Studies

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Contact information

endy@stanford.edu
melsalm@stanford.edu
connhoff@stanford.edu
mjpalmer@stanford.edu

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