Inducing and mapping cellular reprogramming by transcription factor overexpression
Abstract/Contents
- Abstract
- The capability to directly convert one cell type into another by transcription factor overexpression is a modern marvel of biology. Recent advances have suggested that this process can principally convert any cell type to any cell type without restriction to germline origin or tissue. In this thesis, I demonstrate that FoxG1, Sox2 and Brn2 can directly convert fibroblasts into neural precursor cells. These cells can self-renew, differentiate into functional neurons, astrocytes and oligodendrocytes and integrate into the mouse brain. Additionally, this thesis demonstrates my work in induced pluripotent stem cell reprogramming where I identified a series of early intermediates that allowed us to interrogate the mechanism involved during early reprogramming induction.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2015 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lujan, Ernesto George |
|---|---|
| Associated with | Stanford University, Department of Genetics. |
| Primary advisor | Wernig, Marius |
| Thesis advisor | Wernig, Marius |
| Thesis advisor | Baker, Julie, (Professor of genetics) |
| Thesis advisor | Fire, Andrew Zachary |
| Thesis advisor | Stearns, Tim |
| Advisor | Baker, Julie, (Professor of genetics) |
| Advisor | Fire, Andrew Zachary |
| Advisor | Stearns, Tim |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Ernesto George Lujan. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Ernesto George Lujan
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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