Engineering intestinal microenvironments
Abstract/Contents
- Abstract
- Intestinal tissue engineering efforts are motivated by both traditional regenerative medicine incentives and the need for physiologically-relevant in vitro models for scientific study. In this work, engineering of the biomechanical and biochemical cues provided by the in vitro microenvironment is used to improve the yield and functionality of primary intestinal cultures and to establish cell line-based intestinal models that can more accurately model healthy tissue function. In whole, this demonstrates the tremendous impact that microenvironmental cues can have on intestinal cell viability, development, maturation, and ultimately in the establishment of physiologically-relevant functionalities in vitro. Furthermore, the achievements presented in this work directly constitute significant advancements in the field of intestinal tissue engineering and provide valuable insight for the continued development of in vitro culture techniques for autologous tissue expansion and the establishment of a new generation of preclinical drug screening models with improved physiological accuracy.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | DiMarco, Rebecca L |
|---|---|
| Associated with | Stanford University, Department of Bioengineering. |
| Primary advisor | Heilshorn, Sarah |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Cochran, Jennifer R |
| Thesis advisor | Dunn, Alexander Robert |
| Advisor | Cochran, Jennifer R |
| Advisor | Dunn, Alexander Robert |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Rebecca L. DiMarco. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Rebecca Lee DiMarco
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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