A protein acyltransferase complex regulates nonapoptotic cell death
Abstract/Contents
- Abstract
- The synthetic oxime caspase-independent lethal 56 (CIL56) induces an unconventional form of cell death distinct from apoptosis, necroptosis, ferroptosis, and classic necrosis. CIL56-induced cell death requires a protein acyltransferase (PAT) complex comprised of the enzyme ZDHHC5 and an accessory subunit, GOLGA7. ZDHHC5 activity promotes cell death in the context of CIL56 treatment, which inhibits protein secretion from the Golgi apparatus. These results define a novel PAT complex that regulates an unconventional form of nonapoptotic cell death in response to compound treatment.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Ko, Pin-Joe |
|---|---|
| Degree supervisor | Dixon, Scott |
| Thesis advisor | Dixon, Scott |
| Thesis advisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Gozani, Or Pinchas |
| Thesis advisor | Kopito, Ron Rieger |
| Degree committee member | Bertozzi, Carolyn R, 1966- |
| Degree committee member | Gozani, Or Pinchas |
| Degree committee member | Kopito, Ron Rieger |
| Associated with | Stanford University, Department of Biology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Pin-Joe Ko. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Pin-Joe Ko
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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