Novel biomaterials for enhanced spatiotemporal control of adjuvant delivery to improve immune activation
Abstract/Contents
- Abstract
- While prophylactic vaccines and immune checkpoint inhibitors are two of the greatest medical feats of all time, they have come nowhere near fully eradicating infectious disease or cancer, respectively. The primary challenge to developing immunotherapies that work for all patients and across all disease states is that our immune system is incredibly complex. Many cues must be provided to our immune system in a coordinated manner -- considering both timing and location -- to realize the full effects of immunotherapy. Fortunately, our understanding of how our immune system interacts with pathogens and vaccines has grown enormously over recent decades, allowing for the development of more targeted immunotherapies. For example, we now have a thorough understanding of the downstream changes that follow activation of a wide array of pattern recognition receptors (PRRs) that recognize different danger signals, or adjuvant molecules. By combining our understanding of immunology with our understanding of novel biomaterials that can provide levers for controlling presentation, biodistribution, and kinetics of therapeutics, we can incorporate adjuvants into vaccines and cancer therapies in a manner that overcomes limitations of canonical immunotherapy. In my thesis, I have focused on engineering methods for polymer-based delivery of adjuvants to both improve the efficacy of and reduce the toxicity of subunit vaccines and immune checkpoint inhibitors.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Gale, Emily Claire |
|---|---|
| Degree supervisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Kim, Peter, 1958- |
| Thesis advisor | Li, Lingyin |
| Degree committee member | Kim, Peter, 1958- |
| Degree committee member | Li, Lingyin |
| Associated with | Stanford University, Department of Biochemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Emily C. Gale. |
|---|---|
| Note | Submitted to the Department of Biochemistry. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/rg119xj8026 |
Access conditions
- Copyright
- © 2021 by Emily Claire Gale
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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