Photoacoustic molecular imaging and its biomedical applications
Abstract/Contents
- Abstract
- Biomedical imaging has seen a tremendous shift over the past decades, moving to non-invasive and high spatial-resolution imaging, spanning multiple imaging modalities and applications. However, one common limitation of traditional medical imaging is its intrinsic inability to provide information on the molecular levels of various biomarkers. Molecular Imaging solves this limitation by introducing an exogenous imaging agent that upon administration to the subject, binds to or interacts with the molecular target(s) and produces an imaging signal. The agent can be designed to produce the imaging signal in the form of visible fluorescent light, gamma rays, ultrasound waves and other forms of energy. In this thesis, we summarize our work on Photoacoustic Molecular Imaging, a technique where short laser light pulses are converted into ultrasound waves by a nanoparticle that was molecularly targeted to a diseased site. We summarize the physical basis for the technique and its first demonstration -- highlighting angiogenesis markers in living subjects (Chapter 2). We then summarize the development of second generation photoacoustic imaging agents and demonstrate their utility in ultrahigh sensitivity molecular imaging of tumors (Chapter 3) as well as in multiplexing studies (Chapter 4). Next, we describe a novel application for Photoacoustic Imaging in visualizing the retina and the posterior eye segment with unprecedented depth of penetration, giving hope for early diagnosis of age-related macular degeneration and other retinal diseases (Chapter 5). We then describe a novel molecular imaging technology called Optical Coherence Contrast Imaging, and demonstrate it provides ultrahigh resolution and sensitivity images of gold nanoparticles in living mice eyes (Chapter 6). Finally, we conclude with various therapeutic and theranostic (therapy and diagnostic combined) concepts and highlight the synergy between them and the imaging methods presented in earlier chapters (Chapter 7).
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2011 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | De la Zerda, Adam |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering. |
| Primary advisor | Gambhir, Sanjiv Sam |
| Thesis advisor | Gambhir, Sanjiv Sam |
| Thesis advisor | Harris, J. S. (James Stewart), 1942- |
| Thesis advisor | Wang, Shan |
| Advisor | Harris, J. S. (James Stewart), 1942- |
| Advisor | Wang, Shan |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Adam de la Zerda. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Ph.D. Stanford University 2011 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2011 by Adam de la Zerda
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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