A longitudinal analysis of the human immune repertoire
Abstract/Contents
- Abstract
- The human immune system is crucial for maintaining our health throughout our entire lives. In spite of its importance, we still do not fully understand 1) what a healthy immune baseline is, 2) how this baseline changes over time, 3) how the healthy baseline responds to natural infection, and 4) how class switching plays in to creating and maintaining this healthy baseline. To this end, I analyzed the immune repertoire dynamics of a healthy individual. I accomplished this by profiling the B cell receptors of a relatively healthy individual through two periods of infection to better understand how a healthy immune repertoire responds to everyday life versus an infectious challenge. I found that a healthy immune repertoire fluctuates within predetermined patterns during periods of infection and that longitudinal profiling allows the determination of a personal baseline immune repertoire that can be used as both a personal standard for future medical care and a public resource for future studies.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Mitsunaga, Erin M |
|---|---|
| Associated with | Stanford University, Department of Genetics. |
| Primary advisor | Snyder, Michael, Ph. D |
| Thesis advisor | Snyder, Michael, Ph. D |
| Thesis advisor | Fire, Andrew Zachary |
| Thesis advisor | Salit, Marc L |
| Advisor | Fire, Andrew Zachary |
| Advisor | Salit, Marc L |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Erin M. Mitsunaga. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Erin Michiko Mitsunaga
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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