Functional analysis of polarity protein dynamics in the Arabidopsis stomatal lineage
Abstract/Contents
- Abstract
- Cell polarity features the asymmetric distribution of molecules and structures. The establishment of cell polarity allows cells to spatially organize diverse cellular processes, including orienting cell division planes, assuring directional transport of nutrients and hormones, and determining cell morphology and fate. In both animals and plants, cell polarity is established and maintained by so-called "polarity proteins", whose subcellular localization is markedly asymmetric. Precision in the polar localization pattern of polarity proteins, in both space and time, is crucial for the development and functions of the hosting cells. In the past two decades, many polarity proteins have been identified; the cellular functions of most of these polarity proteins, however, remain to be determined. In the stomatal lineage of Arabidopsis thaliana, polarity proteins BASL (BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE) and BRXf (the protein family of BREVIS RADIX) interact and polarly localize to a fraction of the membrane before the onset of an asymmetric cell division (ACD). How BASL and BRXf achieve and maintain their striking polarity and how the dynamics of their polarity in different stages of ACD are connected to their functions are largely unknown. In this dissertation, I combine long-term live imaging, quantitative image analysis, genetics, and developmental biology approaches to explore different avenues of BASL/BRXf polarity and the connections of their polarity to their functions in regulating ACD, thereby providing a mechanistic view of cell polarity and ACD regulations in plants
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Gong, Yan, (Researcher in molecular biology) |
|---|---|
| Degree supervisor | Bergmann, Dominique |
| Thesis advisor | Bergmann, Dominique |
| Thesis advisor | Ehrhardt, David (David Walter) |
| Thesis advisor | Feldman, Jessica L |
| Thesis advisor | Stearns, Tim |
| Thesis advisor | Wang, Zhi-Yong, Dr. |
| Degree committee member | Ehrhardt, David (David Walter) |
| Degree committee member | Feldman, Jessica L |
| Degree committee member | Stearns, Tim |
| Degree committee member | Wang, Zhi-Yong, Dr. |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Yan Gong |
|---|---|
| Note | Submitted to the Department of Biology |
| Thesis | Thesis Ph.D. Stanford University 2021 |
| Location | https://purl.stanford.edu/rb881zd0621 |
Access conditions
- Copyright
- © 2021 by Yan Gong
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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