An essential role of the immune system in remodeling the tumor microenvironment upon oncogene inactivation
Abstract/Contents
- Abstract
- Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4+ T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4+ T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2011 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Rakhra, Kavya |
|---|---|
| Associated with | Stanford University, Department of Immunology. |
| Primary advisor | Felsher, Dean (Dean Walton) |
| Thesis advisor | Felsher, Dean (Dean Walton) |
| Thesis advisor | Krams, Sheri Michele |
| Thesis advisor | Kuo, Calvin Jay |
| Thesis advisor | Levy, Ronald, 1941 December 6- |
| Advisor | Krams, Sheri Michele |
| Advisor | Kuo, Calvin Jay |
| Advisor | Levy, Ronald, 1941 December 6- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Kavya Rakhra. |
|---|---|
| Note | Submitted to the Department of Immunology. |
| Thesis | Ph.D. Stanford University 2011 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2011 by Kavya Rakhra
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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