Nuclear architecture dynamics in tadpole tail regeneration
Abstract/Contents
- Abstract
- Mammals possess very limited regeneration capabilities, where the few examples of scarless healing tend to be restricted to early development. In light of this, it is of great interest to study animals that can faithfully regrow complete appendages, and uncover the biological properties that facilitate regeneration. Xenopus tropicalis is an excellent vertebrate model of regeneration, as tadpoles rapidly regenerate amputated tails, a process that has an interesting developmental history that may be widely informative as to why mammals selectively heal through scarring as they age. Though we have some understanding of what processes are required for tail regeneration, we have yet to systematically chronicle the molecular and regulatory events that must set up an apparently coordinated response. In this dissertation, I address two primary questions in the field of regeneration—what molecular events occur in the first 24 hours to set up a potent regenerative bud, and how is this process regulated? In Chapter 2, I chronicle the transcriptional history of tadpole tail regeneration, focusing primarily within the first 24 hours post amputation. In Chapter 3, I describe a novel nuclear morphology I identified in the tadpole tail, detail how nuclei change shape as an early regeneration response, and investigate the relationship between nuclear shape and chromatin state. Finally, in Chapter 4, I address several future directions with respect to this thesis.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Chang, Jessica Kay |
|---|---|
| Degree supervisor | Baker, Julie, (Professor of genetics) |
| Degree committee member | Bergmann, Dominique |
| Degree committee member | Kundaje, Anshul, 1980- |
| Degree committee member | Villeneuve, Anne, 1959- |
| Thesis advisor | Bergmann, Dominique |
| Thesis advisor | Kundaje, Anshul, 1980- |
| Thesis advisor | Villeneuve, Anne, 1959- |
| Associated with | Stanford University, Department of Genetics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Jessica Kay Chang. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Jessica Kay Chang
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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