A study on the biological and physical effects of radiation on lung and skin in mice
Abstract/Contents
- Abstract
- Radiation therapy is one of the main treatments against cancer. Approximately 50% of all cancer patients are treated with radiation therapy. Despite the high utilization rate of radiation in the treatment of cancer, not all biological effects of radiation on living tissues are understood. Here, I describe my research on two such effects: radiation-induced enhanced growth of cancer cells in irradiated tissue, and the lower toxicity of ultrahigh dose-rate radiation on skin tissue. The first part of this dissertation describes my work on studying the effect of radiation in enhancing the growth of circulating cancer cells in irradiated tissues. Here, I show that radiation enhances the growth of three different breast cancer cell lines in irradiated lung tissue injected into the circulation of immunodeficient mice. I also show that this phenomenon is regulated by T cells, as radiation is unable to enhance the growth of circulating breast cancer cells in immunocompetent mice, but after depletion of T cells, the effect is the same as in immunodeficient mice. The second part of this dissertation focuses on the lower toxicity associated with the delivery of ultrahigh dose-rate radiation to living tissues. I show that FLASH radiation is less toxic to skin tissue in mice than conventional dose-rate radiation. I also show that FLASH radiation is associated with decreased mortality in mice following hemithoracic irradiation compared to conventional dose-rate radiation. In conclusion, this dissertation focuses on two biological and physical effects of radiation that are not fully understood and aims to expand and contribute to the knowledge in the fields of radiation and cancer biology.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Soto, Luis Armando |
|---|---|
| Degree supervisor | Graves, Edward (Edward Elliot), 1974- |
| Thesis advisor | Graves, Edward (Edward Elliot), 1974- |
| Thesis advisor | Engleman, Edgar G |
| Thesis advisor | Rankin, Erinn |
| Thesis advisor | Sage, Julien |
| Degree committee member | Engleman, Edgar G |
| Degree committee member | Rankin, Erinn |
| Degree committee member | Sage, Julien |
| Associated with | Stanford University, Cancer Biology Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Luis Armando Soto. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/qy772ns1776 |
Access conditions
- Copyright
- © 2021 by Luis Armando Soto
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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