Investigating the role of mTOR in ferroptosis
Abstract/Contents
- Abstract
- Bioactive compounds are useful probes for cellular activity. From a library of 1,833 bioactive compounds we identified dozens of small molecule inhibitors of ferroptosis, including investigational and FDA-approved drugs, with unexpected off-target antioxidant activities. ATP-competitive mechanistic target of rapamycin (mTOR) inhibitors, by contrast, were on-target ferroptosis inhibitors. These results highlight widespread bioactive compound pleiotropy and link mTOR signaling to ferroptosis regulation.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Conlon, Megan Marie |
|---|---|
| Degree supervisor | Dixon, Scott |
| Thesis advisor | Dixon, Scott |
| Thesis advisor | Mudgett, Mary Beth, 1967- |
| Thesis advisor | Stearns, Tim |
| Degree committee member | Mudgett, Mary Beth, 1967- |
| Degree committee member | Stearns, Tim |
| Associated with | Stanford University, Department of Biology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Megan Marie Conlon. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Megan Marie Conlon
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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