The timing and molecular mechanisms of lung adenocarcinoma metastasis
Abstract/Contents
- Abstract
- Metastasis is a complex series of steps leading to the establishment of tumors at secondary sites separate from the primary tumor. Accumulating evidence supports the idea that the metastatic process varies in different cancers. Two main models of the metastatic process exist. The first is referred to as the linear progression model. In this model the primary tumor progresses to full malignancy before tumor cells disseminate from it to form metastases at secondary sites. In the other model, the parallel progression model, metastases seeded from early-disseminated tumor cells independently progress to a late stage in parallel to the primary tumor. Recently the parallel progression model has been shown to occur in both breast and pancreatic tumor mouse models. This work illustrates that in lung cancer, in opposition to breast and pancreatic cancer, dissemination and metastasis occurs at a late stage of tumor progression, after gaining specific alterations that allow tumor cells to metastasize. The exact alterations that allow tumor cells to disseminate and metastasize remain unclear, but in this work it is demonstrated that the lineage transcription factor Nkx2-1 activates a number of targets that are potentially important for metastatic ability. One in particular, Selenbp1, is shown to act in a positive feedback loop with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Using well-established mouse models in combination with massively parallel sequencing this work begins to piece together parts of the metastatic process.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Caswell, Deborah Ruth Mary |
|---|---|
| Associated with | Stanford University, Cancer Biology Program. |
| Primary advisor | Winslow, Monte |
| Thesis advisor | Winslow, Monte |
| Thesis advisor | Attardi, Laura |
| Thesis advisor | Fire, Andrew Zachary |
| Thesis advisor | Lipsick, Joseph Steven, 1955- |
| Advisor | Attardi, Laura |
| Advisor | Fire, Andrew Zachary |
| Advisor | Lipsick, Joseph Steven, 1955- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Deborah Ruth Mary Caswell. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Deborah Ruth Caswell
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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