Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment in five human cell lines
Abstract/Contents
- Abstract
- The human genome's nucleotide sequence contains a small amount of information relative to the complexity of the organism. The diversity of developmental programs and stimulus responses is instead enabled by a vast regulatory network of chemical modifications and protein interactions that determine the activity level of each genome element dynamically. Recent advances in molecular profiling techniques have led to the creation of large data sets that assay each regulatory interaction across the entire genome at once, with high sensitivity and precision. Here I introduce a new computational method, UniPeak, that synthesizes the output from any number of these experiments into a single straightforward analysis with rigorous quantitative measures. I then apply this method to the largest available data sets of genome regulation experiments, and integrate them with parallel experiments on genome activity. I discover and characterize novel regulatory interactions, and model how these interactions regulate the activity of genes.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2013 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Foley, Joseph William |
|---|---|
| Associated with | Stanford University, Department of Genetics |
| Primary advisor | Sidow, Arend |
| Thesis advisor | Sidow, Arend |
| Thesis advisor | Baker, Julie, (Professor of genetics) |
| Thesis advisor | Fire, Andrew Zachary |
| Thesis advisor | Sherlock, Gavin |
| Advisor | Baker, Julie, (Professor of genetics) |
| Advisor | Fire, Andrew Zachary |
| Advisor | Sherlock, Gavin |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Joseph William Foley. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Joseph William Foley
- License
- This work is licensed under a Creative Commons Attribution Non Commercial Share Alike 3.0 Unported license (CC BY-NC-SA).
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