Single-molecule and computational studies of DNA torsional dynamics : from fundamental biophysics to anticancer therapeutics
Abstract/Contents
- Abstract
- The torsional mechanics of DNA have been exploited by evolution to achieve exceedingly sophisticated levels of biological control. Yet, how these mechanics dictate genetic function remains underexplored, limiting both our understanding of basic biological phenomena and our ability to fine-tune synthetic systems for biotechnological applications. In this dissertation, I present a series of biophysical studies based on molecular modeling and single-molecule measurements, each providing mechanistic insight into genetic phenomena through consideration of DNA topology and supercoiling.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Starr, Charles Hancock |
|---|---|
| Degree supervisor | Bryant, Zev David |
| Thesis advisor | Bryant, Zev David |
| Thesis advisor | Greenleaf, William James |
| Thesis advisor | Spakowitz, Andrew James |
| Degree committee member | Greenleaf, William James |
| Degree committee member | Spakowitz, Andrew James |
| Associated with | Stanford University, Biophysics Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Charles Starr. |
|---|---|
| Note | Submitted to the Biophysics Program. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/qn396fv6599 |
Access conditions
- Copyright
- © 2022 by Charles Hancock Starr
- License
- This work is licensed under a Creative Commons Attribution Non Commercial No Derivatives 3.0 Unported license (CC BY-NC-ND).
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