Large-scale two-photon microscopy studies of sensory neural coding
Abstract/Contents
- Abstract
- Understanding the functions of the brain has been a subject of intensive scientific interest for centuries. At the level of individual neurons, there is a relatively detailed understanding of the mechanisms of spiking, signaling between individual cells and extensive categorization of neuron types. Similarly, at the large scale, many studies advanced our knowledge about the organization of brain regions by their function. However, the fundamental principles of neural coding at the scale of hundreds up to thousands of neurons remain largely unknown. One of the main obstacles to studying neural networks in the living brain has been a lack of technologies allowing simultaneous recording of activity across large populations of cells. In this dissertation, I first present a two-photon microscope capable of imaging the calcium dynamics of more than 2000 neurons simultaneously in awake mice. I then present an experiment that uses this new microscope to address longstanding questions in neuroscience regarding the extent to which correlated variability of neuronal responses affects the accuracy of the neural population code. I show that in the mouse visual cortex, noise correlations lead to a substantial decrease and saturation of information capacity with growing population size. I further demonstrate evidence for the presence of information-limiting 'differential' correlations. Finally, I present a theoretical model that shows how the connectivity in a hierarchical neural network may define the structure of such correlations.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Rumyantsev, Oleg I |
|---|---|
| Associated with | Stanford University, Department of Applied Physics. |
| Primary advisor | Schnitzer, Mark Jacob, 1970- |
| Thesis advisor | Schnitzer, Mark Jacob, 1970- |
| Thesis advisor | Ganguli, Surya, 1977- |
| Thesis advisor | Moore, Tirin, 1969- |
| Advisor | Ganguli, Surya, 1977- |
| Advisor | Moore, Tirin, 1969- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Oleg I. Rumyantsev. |
|---|---|
| Note | Submitted to the Department of Applied Physics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Oleg Igorevich Rumyantsev
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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