Methods for measuring selection on coding regulatory elements and gene expression divergence between human and chimpanzee brain development in vitro

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In this dissertation, I explore the impact of gene expression changes on human evolution in two distinct contexts. In chapter 2, I describe a method of quantifying the relative contributions of coding and non-coding changes in driving selection at three regulatory loci in the human genome. In chapter 3, I describe a novel system for quantifying cis- regulatory gene expression divergence between the human and chimpanzee genomes during fetal brain development in vitro. Overall, this body of work highlights the importance of precise methodology for understanding the role of gene regulation in human evolution


Type of resource text
Form electronic resource; remote; computer; online resource
Extent 1 online resource
Place California
Place [Stanford, California]
Publisher [Stanford University]
Copyright date 2020; ©2020
Publication date 2020; 2020
Issuance monographic
Language English


Author Agoglia, Rachel Marie
Degree supervisor Fraser, Hunter B
Thesis advisor Fraser, Hunter B
Thesis advisor Baker, Julie, (Professor of genetics)
Thesis advisor Montgomery, Stephen, 1979-
Thesis advisor Pritchard, Jonathan D
Degree committee member Baker, Julie, (Professor of genetics)
Degree committee member Montgomery, Stephen, 1979-
Degree committee member Pritchard, Jonathan D
Associated with Stanford University, Department of Genetics.


Genre Theses
Genre Text

Bibliographic information

Statement of responsibility Rachel M. Agoglia
Note Submitted to the Department of Genetics
Thesis Thesis Ph.D. Stanford University 2020
Location electronic resource

Access conditions

© 2020 by Rachel Marie Agoglia
This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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