Methods for measuring selection on coding regulatory elements and gene expression divergence between human and chimpanzee brain development in vitro
Abstract/Contents
- Abstract
- In this dissertation, I explore the impact of gene expression changes on human evolution in two distinct contexts. In chapter 2, I describe a method of quantifying the relative contributions of coding and non-coding changes in driving selection at three regulatory loci in the human genome. In chapter 3, I describe a novel system for quantifying cis- regulatory gene expression divergence between the human and chimpanzee genomes during fetal brain development in vitro. Overall, this body of work highlights the importance of precise methodology for understanding the role of gene regulation in human evolution
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Agoglia, Rachel Marie |
|---|---|
| Degree supervisor | Fraser, Hunter B |
| Thesis advisor | Fraser, Hunter B |
| Thesis advisor | Baker, Julie, (Professor of genetics) |
| Thesis advisor | Montgomery, Stephen, 1979- |
| Thesis advisor | Pritchard, Jonathan D |
| Degree committee member | Baker, Julie, (Professor of genetics) |
| Degree committee member | Montgomery, Stephen, 1979- |
| Degree committee member | Pritchard, Jonathan D |
| Associated with | Stanford University, Department of Genetics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Rachel M. Agoglia |
|---|---|
| Note | Submitted to the Department of Genetics |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Rachel Marie Agoglia
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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