Enantioselective chlorination in the synthesis of polychlorinated natural products
Abstract/Contents
- Abstract
- Organochlorides are pervasive in nature, accounting for over 2,500 natural products. This is perhaps not surprising as the ocean covers > 70% of the earth's surface and is rich in soluble chloride. Approximately half of naturally occurring organochlorides contain chlorine-bearing chiral centers. The abundance of chiral organochlorides in nature stands in stark contrast to the number of methods for asymmetric chlorination. Recent work in the synthesis of molecules with chlorine-bearing stereocenters has addressed this methodological deficiency through multistep functional group interconversions. The advent of synthetically relevant, catalytic, enantioselective methods for the direct formation of carbon-chlorine bonds would be of great value in the synthesis of chiral organochlorides. This thesis outlines the development of two new methods for enantioselective chlorofunctionalization of olefins and their application in the synthesis of natural products.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Landry, Matthew |
|---|---|
| Degree supervisor | Burns, Noah |
| Thesis advisor | Burns, Noah |
| Thesis advisor | Du Bois, Justin |
| Thesis advisor | Xia, Yan |
| Degree committee member | Du Bois, Justin |
| Degree committee member | Xia, Yan |
| Associated with | Stanford University, Department of Chemistry. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Matthew Landry. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Matthew Leo Landry
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...