A microfluidic biochip based on magnetoresistive detection of nanoparticles
Abstract/Contents
- Abstract
- The detection of magnetic nanoparticle (MNP) labels is a promising alternative to optical detection of fluorescent labels in biomolecular assays, in part because MNPs are not susceptible to pH, bleaching, or autofluorescence, but especially because microscopic quantities of MNPs can be detected with simple and inexpensive magnetoresistive sensors such as spin valves. The goal of this dissertation was to develop and demonstrate a biochip based on this detection principle. The particular novelty of this work is the extensive demonstration of magnetic biochips in real assays, the establishment of a compatible microfluidic fabrication process, and the development of a simple mathematical model which explains the experimentally observed signal scaling trends.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Copyright date | 2010 |
| Publication date | 2009, c2010; 2009 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Osterfeld, Sebastian Jeremias |
|---|---|
| Associated with | Stanford University, Department of Materials Science and Engineering |
| Primary advisor | Wang, Shan X |
| Thesis advisor | Wang, Shan X |
| Thesis advisor | Melosh, Nicholas A |
| Thesis advisor | White, Robert L. (Robert Lee), 1927- |
| Advisor | Melosh, Nicholas A |
| Advisor | White, Robert L. (Robert Lee), 1927- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Sebastian Jeremias Osterfeld. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Ph.D. Stanford University 2010 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2010 by Sebastian Jeremias Osterfeld
- License
- This work is licensed under a Creative Commons Attribution Non Commercial Share Alike 3.0 Unported license (CC BY-NC-SA).
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