High-valent copper-dioxygen assemblies : synthesis, characterization, and potential relevance to biological systems
Abstract/Contents
- Abstract
- Biological enzymes utilize various copper-based active sites to activate dioxygen creating a variety of copper-dioxygen assemblies. These assemblies carry out highly selective and difficult oxidative transformations vital to biological life. Insight into how Nature has optimized these active sites can be gleaned by studying synthetic structural mimics and has potential to be of great benefit to the industrial design of catalysts. While the resting structures of many of these active sites are known, the nature of the active oxidants are often less well-defined. In this thesis, efforts towards the cryogenic synthesis and spectroscopic characterization of copper(III)-containing oxidants, formed directly via dioxygen activation of biomimetic copper precursors, will be discussed. This work demonstrates both the kinetic and thermodynamic accessibility of the copper(III) oxidation state under biological ligation, which challenges existing assumptions in the literature through the identification of reactive intermediates.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Keown, William Jay |
|---|---|
| Degree supervisor | Stack, T. (T. Daniel P.), 1959- |
| Thesis advisor | Stack, T. (T. Daniel P.), 1959- |
| Thesis advisor | Cui, Yi, 1976- |
| Thesis advisor | Solomon, Edward I |
| Degree committee member | Cui, Yi, 1976- |
| Degree committee member | Solomon, Edward I |
| Associated with | Stanford University, Department of Chemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | William Keown. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/pw029qz2487 |
Access conditions
- Copyright
- © 2021 by William Jay Keown
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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