The contribution of innate mechanical properties of epithelian in tissue homeostasis
Abstract/Contents
- Abstract
- Epithelial tissues are subject to stresses either from external or internal environments, as is the case with the epidermis and intestinal epithelia, respectively. One of the stresses epithelia are subject to is mechanical force. Mechanobiology is the study of how tissues, cells and their proteins respond and adapt to mechanical forces. For my thesis work, I have dedicated my research to investigating the effect of mechanical shear force on epithelial collective behavior by fabricating novel biocompatible devices to apply various types of mechanical forces on cell monolayers. Collective behaviors within tissues require cell-cell junctions and studies have shown that epithelial cell-cell junctions are mechanically responsive. However, it is poorly understood how the innate mechanical properties of cells and their junctions contribute to regaining homeostasis when an external force is applied. By applying a localized shear force to the mid-plane of an epithelial monolayer I have revealed that epithelia resist acute forces through their innate mechanical property but also behave as an active material over longer periods of time to regain a balance of force.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Garcia, Miguel Angel |
|---|---|
| Associated with | Stanford University, Department of Biology. |
| Primary advisor | Nelson, W. J. (W. James) |
| Thesis advisor | Nelson, W. J. (W. James) |
| Thesis advisor | Cyert, Martha S, 1958- |
| Thesis advisor | Oro, Anthony, 1958- |
| Thesis advisor | Stearns, Tim |
| Advisor | Cyert, Martha S, 1958- |
| Advisor | Oro, Anthony, 1958- |
| Advisor | Stearns, Tim |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Miguel Angel Garcia. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Miguel Angel Garcia
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...