Synthesis and organization of nanomaterials using biomolecules
Abstract/Contents
- Abstract
- Recent advances in materials synthesis have revealed unique properties that occur at the nanoscale; however, organization of nanomaterials into hierarchical three-dimensional structures remains an unmet challenge. In striking contrast, Nature exhibits control over precise nanoscale processing which leads to highly organized and complex three-dimensional structures. This control is achieved through the action of many molecules, especially a wide array of proteins, that direct the synthesis, morphology, and organization of the many organic and inorganic materials found in Nature. Understanding and applying insights from these natural processes offers a promising new way forward for the manipulation and organization of materials at the nanoscale. This thesis focuses on understanding the unique self-assembling protein clathrin and developing strategies to modify self-assembled clathrin scaffolds for the synthesis and organization of inorganic nanomaterials. I have studied clathrin as an example of a robustly self-assembling protein to gain insight into how self-assembly is achieved in natural systems. I have designed and used bi-functional peptides for functionalization of self-assembled clathrin cage scaffolds through site-specific molecular recognition to generate complexes for the synthesis of two classes of inorganic nanomaterials, metal oxides and noble metals. Additionally, I have demonstrated that a single clathrin-based biomolecular complex can be used to generate distinct arrangements of gold nanoparticles. I have extended the peptide design strategy to design components that will direct hierarchical organization and have demonstrated the importance of considering the effect of multivalent interactions in peptide-mediated assembly. Taken together, the results presented provide insight to aid in the design of novel biomimetic systems for the tunable control over nanoscale synthesis and organization.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2013 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Schoen, Alia Patricia |
|---|---|
| Associated with | Stanford University, Department of Materials Science and Engineering. |
| Primary advisor | Heilshorn, Sarah |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Melosh, Nicholas A |
| Thesis advisor | Spakowitz, Andrew James |
| Advisor | Melosh, Nicholas A |
| Advisor | Spakowitz, Andrew James |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Alia Patricia Schoen. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Alia Patricia Schoen
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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