Characterization of the long noncoding RNA DINO in the DNA damage response and JUN in cutaneous scarring
Abstract/Contents
- Abstract
- Long noncoding RNAs (lncRNAs) are emerging as important regulatory elements involved at different levels of regulation. Several lncRNAs have been identified as part of the p53 network. The p53-dependent response is critical for normal cell proliferation and suppression of cancer. It is known that sustained DNA damage stabilizes p53, and p53-responsive genes are activated, leading to cell cycle arrest, apoptosis, or senescence. However, the specificity of this response needs further study. It is thought this response elicits a signal amplification mechanism that needs a p53 co-activator because fine-tuning the choice and amplitude of p53 target genes is a critical aspect. In this dissertation, I described the characterization of the novel, long noncoding RNA DINO as a key component of p53-dependent DNA damage response. Chapter 2 focuses on identifying the role of DINO in guiding organismal response to DNA damage as part of the p53-dependent response. Chapter 3 focuses on investigating Dino's contribution to p53-dependent transcriptional heterogeneity in response to DNA damage at the single-cell level. Chapter 4 describes the work done to study the transcription factor JUN as a critical regulator of skin scarring through the regulation of CD36
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Garcia, Julia Teresa |
|---|---|
| Degree supervisor | Chang, Howard Y. (Howard Yuan-Hoa), 1972- |
| Thesis advisor | Chang, Howard Y. (Howard Yuan-Hoa), 1972- |
| Thesis advisor | Attardi, Laura |
| Thesis advisor | Fire, Andrew Zachary |
| Thesis advisor | Greenleaf, William James |
| Degree committee member | Attardi, Laura |
| Degree committee member | Fire, Andrew Zachary |
| Degree committee member | Greenleaf, William James |
| Associated with | Stanford University, Department of Genetics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Julia Teresa Garcia-Daou |
|---|---|
| Note | Submitted to the Department of Genetics |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Julia Teresa Garcia
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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