Brain mapping and plasticity induction using non-invasive brain stimulation
Abstract/Contents
- Abstract
- Transcranial magnetic stimulation (TMS) is a form of non-invasive brain stimulation, which can be paired with concurrent electroencephalography (EEG). Low frequency (~0.5 Hz) stimulation, commonly called single-pulse TMS (spTMS), has been used as a measurement of cortical responsivity (i.e., stimulus-response mapping). Higher frequen-cy (1 -- 20 Hz) repetitive TMS (rTMS) has been used as a therapeutic tool, producing longer lasting effects that have been shown to reduce symptoms especially in major de-pressive disorder. However, there are major limitations to our efficient use of TMS. Re-sponse to TMS is highly variable both within and between subjects, and there is little un-derstanding about the source of this variance. In the following projects, we characterized changes in the TMS-EEG response across key dimensions: In Chapter 2, we used spTMS to probe the entirety of the accessible cortex, mapping changes in the evoked response as a function of spatial location. Additionally, we linked these changes in TMS evoked response to anatomical and resting state connectivity properties of each target brain region. In Chapter 3, we varied stimulation burst frequency, intensity, and burst length, evaluat-ing the input parameter space of rTMS considered safe in healthy humans and clinical populations. Using a series of common TMS-EEG output measures, we tracked how these three parameters could be selected for to maximize each unique output metric. Chapter 4 describes a custom fully-automated data processing pipeline developed for the aforementioned studies, each of which used TMS-EEG in analytically challenging ways. Overall, our hope is to better understand what drives TMS-induced changes in the brain such that future work can capitalize on these properties for more optimal results.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Lucas, Molly Vanneman |
|---|---|
| Degree supervisor | Poldrack, Russell A |
| Thesis advisor | Poldrack, Russell A |
| Thesis advisor | Etkin, Amit, 1976- |
| Thesis advisor | Malenka, Robert C |
| Thesis advisor | Newsome, William T |
| Degree committee member | Etkin, Amit, 1976- |
| Degree committee member | Malenka, Robert C |
| Degree committee member | Newsome, William T |
| Associated with | Stanford University, Neurosciences Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Molly Vanneman Lucas. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/pk260ng3138 |
Access conditions
- Copyright
- © 2021 by Molly Vanneman Lucas
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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