Fluorescence-based R-loop detection : characterization of cellular RNA-DNA hybrid signals
Abstract/Contents
- Abstract
- In this work, we present an improved fluorescence-based R-loop detection method that is more accurate and specific compared to the current standard practice of using the S9.6 antibody in immunofluorescence applications. We used this new procedure to characterize and provide novel insights on cellular RNA-DNA hybrid signals. Additionally, we investigated the nucleotide excision repair (NER)-mediated R-loop processing and explored the mechanisms underlying its impact on genome stability.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Kao, Yung-Hsin |
|---|---|
| Degree supervisor | Cimprich, Karlene |
| Thesis advisor | Cimprich, Karlene |
| Thesis advisor | Feldman, Jessica L |
| Thesis advisor | Gozani, Or Pinchas |
| Degree committee member | Feldman, Jessica L |
| Degree committee member | Gozani, Or Pinchas |
| Associated with | Stanford University, Department of Biology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Yung-Hsin Kao. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Yung-Hsin Kao
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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