Ferroptosis regulation by protein catabolism
Abstract/Contents
- Abstract
- The extracellular environment contains diverse nutrients. How these nutrients are acquired and utilized by cells to promote survival and proliferation and prevent cell death is not entirely clear. In recent years, there has been increasing attention paid to different kinds of regulated cell death, including apoptosis, necroptosis, and ferroptosis. Ferroptosis is an oxidative, iron-dependent form of nonapoptotic cell death characterized by lipid peroxidation. Ferroptosis can occur when a cell is deprived of cysteine and thereby rendered incapable of synthesizing the antioxidant tripeptide glutathione. Here I describe a mechanism by which cancer cells can evade ferroptosis during cystine deprivation via the internalization and lysosomal catabolism of extracellular protein, providing an alternative source of cysteine. Once internalized by the cell, exogenous protein must be trafficked to the lysosome where it is catabolized by proteases, especially cathepsin B. Newly liberated cysteine can then be exported from the lysosome by the transporter cystinosin and fuel the synthesis of reduced glutathione to prevent death by ferroptosis. Different cell types may internalize and traffic protein through different processes. This work elucidates an important mechanism by which cancer cells can evade cell death, suggesting possible avenues for future cancer therapy.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Armenta, David Alexander |
|---|---|
| Degree supervisor | Dixon, Scott James, 1977- |
| Thesis advisor | Dixon, Scott James, 1977- |
| Thesis advisor | Frydman, Judith |
| Thesis advisor | Stearns, Tim |
| Thesis advisor | Ye, Jiangbin |
| Degree committee member | Frydman, Judith |
| Degree committee member | Stearns, Tim |
| Degree committee member | Ye, Jiangbin |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | David Alexander Armenta. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/ny500ch8809 |
Access conditions
- Copyright
- © 2022 by David Alexander Armenta
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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