Geographical Differences in Lifestyle Risk Factors for Endometrial Cancer Diagnosis, Treatment and Survival: The Women’s Health Initiative Longitudinal Cohort
Abstract/Contents
- Abstract
- Endometrial cancer is a prevalent gynecologic cancer in the United States, with high incidence and mortality rates, particularly among postmenopausal women. Obesity is a significant risk factor for endometrial cancer, and studies have shown significant racial disparities in endometrial cancer outcomes. We utilized the Women’s Health Initiative study to compare baseline demographic and lifestyle factors, e.g., physical activity, body mass index, diet, alcohol consumption, smoking, education, etc.) across the four United States census geographic regions among women who were diagnosed with endometrial cancer (N=1803) compared to those without endometrial cancer (N=92,054). Our analysis revealed moderate differences in self-reported race and BMI between women with and without endometrial cancer. When comparing endometrial cancer patients across geographic regions, similar BMI trends were observed, but significant differences in self-reported race were only apparent in the West and South. We also found that the incidence and survival of endometrial cancer did not exhibit substantial variations based on geographic location, suggesting that region may not strongly influence these outcomes. While the Northeast and West had slightly higher incidence rates compared to the South and Midwest, these differences did not reach statistical significance. Additionally, the analysis of histology and stage revealed geographic disparities in the prevalence of serous/papillary serous carcinoma and disease stage, with the highest proportion being in the Northeast. However, overall survival rates did not significantly vary across geographic regions. Overall, these findings enhance our understanding of endometrial cancer epidemiology and underscore the significance of considering racial disparities and histologic subtypes in the study of this disease.
Description
| Type of resource | text |
|---|---|
| Publication date | June 6, 2023 |
Creators/Contributors
| Author | Somasegar, Sahana |
|---|---|
| Thesis advisor | Kurian, Allison |
| Research team head | Stefanick, Marcia |
| Contributor | Hedlin, Haley |
Subjects
| Subject | Uterus > Cancer |
|---|---|
| Subject | Regional disparities |
| Genre | Text |
| Genre | Thesis |
Bibliographic information
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- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
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- This work is licensed under a Creative Commons Attribution 4.0 International license (CC BY).
Preferred citation
- Preferred citation
- Somasegar, S., Kurian, A., Stefanick, M., and Hedlin, H. (2023). Geographical Differences in Lifestyle Risk Factors for Endometrial Cancer Diagnosis, Treatment and Survival: The Women’s Health Initiative Longitudinal Cohort. Stanford Digital Repository. Available at https://purl.stanford.edu/nx563ph8536. https://doi.org/10.25740/nx563ph8536.
Collection
Epidemiology & Clinical Research Masters Theses
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- Contact
- ssomasegar@gmail.com
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