Photoacoustic imaging using capacitive micromachined ultrasonic transducers
Abstract/Contents
- Abstract
- One of the primary goals of a medical imaging procedure is to spatially localize disease in an individual. This dissertation focuses on photoacoustic imaging, which is a relatively new medical imaging modality that shows great promise for disease diagnosis - especially cancer detection. In photoacoustic imaging, short laser pulses absorbed by molecules in tissue induce ultrasonic pressure waves which are then detected to form an image. In this work, using a custom built mechanically scanned single-transducer photoacoustic imaging system, we extend photoacoustic imaging into the molecular imaging domain. In this first such demonstration, we show how an exogenous contrast agent that binds preferentially to an angiogenesis biomarker enables an early cancer diagnosis in living subjects. To accelerate the goal of taking photoacoustic imaging from the lab to the clinic, this thesis introduces capacitive micromachined ultrasonic transducer (CMUT) arrays as an enabling technology platform. CMUT technology allows the fabrication of highly sensitive, wide bandwidth, 2D transducer arrays that can be tightly integrated with electronics. This thesis shows the first results of true 3D volumetric photoacoustic imaging using CMUTs. Deep tissue photoacoustic imaging up to a depth of ~5 cm and preliminary results from real-time photoacoustic imaging are also shown. Finally, in this work, we describe a new CMUT microfabrication process called the Thick-BOX process. The Thick-BOX process promises a simpler fabrication process that produces more reliable and robust CMUTs. Experimental fabrication results of low frequency CMUT devices are presented as a proof-of-concept verification for this fabrication process.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2012 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Vaithilingam, Srikant |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering |
| Primary advisor | Gambhir, Sanjiv Sam |
| Primary advisor | Khuri-Yakub, Butrus T, 1948- |
| Thesis advisor | Gambhir, Sanjiv Sam |
| Thesis advisor | Khuri-Yakub, Butrus T, 1948- |
| Thesis advisor | Howe, Roger Thomas |
| Advisor | Howe, Roger Thomas |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Srikant Vaithilingam. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2012. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Srikant Vaithilingam
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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