Volumetric optical coherence tomography vibrometry for the study of cochlear mechanics
Abstract/Contents
- Abstract
- Sound is encoded within the auditory portion of the inner ear, the cochlea, after propagating down its length as a traveling wave. For over half a century, vibratory measurements to study cochlear traveling waves have been made using invasive approaches such as laser Doppler vibrometry. Although these studies have provided critical information regarding the nonlinear processes within the living cochlea that increase the amplitude of vibration and sharpen frequency tuning, the data have typically been limited to the surface vibratory measurements of the basilar membrane. This dissertation presents a new vibrometry technique, called volumetric optical coherence tomography vibrometry (VOCTV), which provides depth resolved displacement measurements at high speed inside a 3-D volume of tissue with picometer displacement sensitivity. The mechanics of the mouse cochlea is studied by imaging noninvasively through the surrounding bone to measure sound-induced vibrations of the sensory structures in vivo. Unique vibratory data from inner structures of the cochlea that could not be measured before provided clues to the unsolved questions of how such a complicated microstructure could transduce the complex input sound into neural information efficiently.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lee, Hee Yoon |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering. |
| Primary advisor | Bowden, Audrey, 1980- |
| Thesis advisor | Bowden, Audrey, 1980- |
| Thesis advisor | Nishimura, Dwight George |
| Thesis advisor | Oghalai, John S |
| Advisor | Nishimura, Dwight George |
| Advisor | Oghalai, John S |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Hee Yoon Lee. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Hee Yoon Lee
Also listed in
Loading usage metrics...