A tale of two drugs discovered from natural products : an aldehyde dehydrogenase 3A1 small molecule activator for mitigating radiation-induced injury and a botanical drug for ulcerative colitis
Abstract/Contents
- Abstract
- Approximately 50% of currently available drugs approved by the U.S. Food and Drug Administration (FDA) have been discovered from natural products derived from plants, animals, or microorganisms. Although the pharmaceutical industry has focused modern discovery efforts on screening synthetic libraries, natural products may be a continuing source for new drug discovery. This thesis provides two examples of pharmaceutical agents that were discovered from Traditional Chinese Medicine (TCM). The first, in Part I of this thesis, describes the identification of a single small molecule activator (Alda-341) of aldehyde dehydrogenase 3A1 (ALDH3A1) common to several TCM extracts for the treatment of radiation-induced injuries. The second, in Part II, describes a complex natural mixture (SA100) accepted as an FDA Botanical Investigational New Drug (IND) that was evaluated in a Phase 1b clinical study in patients with ulcerative colitis (UC).
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Saiki, Julie |
|---|---|
| Degree supervisor | Mochly-Rosen, Daria |
| Thesis advisor | Mochly-Rosen, Daria |
| Thesis advisor | Grimes, Kevin |
| Thesis advisor | Le, Quynh-Thu |
| Thesis advisor | Meyer, Tobias |
| Degree committee member | Grimes, Kevin |
| Degree committee member | Le, Quynh-Thu |
| Degree committee member | Meyer, Tobias |
| Associated with | Stanford University, Department of Chemical and Systems Biology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Julie Saiki. |
|---|---|
| Note | Submitted to the Department of Chemical and Systems Biology. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Julie Patricia Saiki
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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